SNT-207858

立即咨询

SNT-207858

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1104080-42-3

SNT-207858 是一种选择性，可渗透血脑屏障的，有口服活性的黑皮质素 (melanocortin; MC-4) 受体拮抗剂，SNT-207858 抑制与 MC-4 受体结合，IC₅₀为 22 nM。SNT-207858 抑制 MC-4 活性，IC₅₀为 11 nM。

生物活性

SNT207858 is a selective, blood brain barrier penetrating, potent and orally activemelanocortin-4(MC-4)receptorantagonist. SNT207858 has anIC₅₀of 22 nM (binding) and 11 nM (function) on the MC-4 receptor^[1].

IC₅₀& Target

IC50: 22 nM (binding, MC-4 receptor), 11 nM (function, MC-4 receptor)^[1]

体外研究
(In Vitro)

SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5^[1].

体内研究
(In Vivo)

SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice^[1].

Animal Model:	Mice with C26 adenocarcinoma-induced cachexia model^[1]
Dosage:	30 mg/kg
Administration:	Oral administration; once daily; 15 days
Result:	Significantly reduced the tumor induced weight loss.

分子量

689.54

Formula

C₃₂H₄₅Cl₄N₅O₃

CAS 号

1104080-42-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.