JKC363 是一种选择性黑素皮质激素MC4受体拮抗剂，在 MC4 受体 (IC50=0.5 nM) 的亲和力比 MC3 受体 (44.9 nM) 高90倍。JKC363 阻断 α-MSH 对 TRH 释放的刺激作用。具有抗痛觉作用。
| 生物活性 | JKC363, a selectivemelanocortin MC4 receptorantagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[1][2]. |
| 分子量 | |
| Formula | |
| CAS 号 | |
| Sequence Shortening | {Mpa}-EH-{D-2-Nal}-RWGCPPKD (Disulfide bridge:Mpa1-Cys8) |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
