YM-298198 hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1216398-09-2

YM-298198 hydrochloride 是高亲和力、选择性的，具有口服活性的，非竞争性的mGluR1的拮抗剂。YM-298198 hydrochloride 可用于神经系统疾病的研究。

生物活性

YM-298198 hydrochloride is a high-affinity, selective, orally active, and non-competitive antagonist ofmetabotropic glutamate receptor type 1 (mGluR1). YM-298198 hydrochloride can be used for the research of neurological disorders^[1].

IC₅₀& Target^[1]

mGluR 1

体外研究
(In Vitro)

YM-298198 hydrochloride shows a high affinity for mGluR1 with a K_iof 19 nM for rat mGluR1-NIH membranes^[1].
YM-298198 hydrochloride inhibits glutamate-induced inositol phosphate production in mGluR1-NIH3T3 cells, with an IC₅₀of 16 nM^[1].
YM-298198 hydrochloride shows neither agonistic nor antagonistic activity on mGluR2, 3, 4a, 6, or 7b up to 10 μM^[1].

体内研究
(In Vivo)

YM-298198 hydrochloride (30 mg/kg; p.o.) shows a significant analgesic effect in streptozotocin-induced hyperalgesic mice^[1].

Animal Model:	Male ICR mice^[1]
Dosage:	30 mg/kg
Administration:	Oral administration
Result:	Prolonged nociceptive response latency in streptozotocin (200 mg/kg)-induced hyperalgesic mice.

分子量

378.92

性状

Solid

Formula

C₁₈H₂₃ClN₄OS

CAS 号

1216398-09-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)