(RS)-PPG

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(RS)-PPG

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

120667-15-4

(RS)-PPG 是一种有效的，选择性 III 型mGluR激动剂。对 hmGluR4a，hmGluR6，hmGluR7b 和 hmGluR8a 的EC₅₀分别为 5.2 μM，4.7 μM，185 μM 和 0.2 μM，具有抗惊厥和神经保护活性。

生物活性

(RS)-PPG is a potent and selective agonist for group IIImGluRs. TheEC₅₀s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity^[1].

IC₅₀& Target^[1]

hmGluR4a

5.2 μM (EC₅₀)

hmGluR6

4.7 μM (EC₅₀)

hmGluR7b

185 μM (EC₅₀)

hmGluR8a

0.2 μM (EC₅₀)

体外研究
(In Vitro)

Activation of group III mGluRs by treatment of neurons with (R,S)-PPG (100 μM) can significantly suppress the elevation of intracellular calcium and protect neurons from apoptosis induced by Aβ[31-35] (25 μM)^[2].

分子量

231.14

Formula

C₈H₁₀NO₅P

CAS 号

120667-15-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.