LSP4-2022 是一种有效的透过血脑屏障的mGlu4选择性正位激动剂，其EC50为 0.11 μM。LSP4-2022 可抑制野生型小鼠小脑切片的神经传递，但不能抑制mGlu4受体敲除小鼠。LSP4-2022 具有促抑郁活性。
| 生物活性 | LSP4-2022 is a potent and brain-penetrantmGlu4-selective orthosteric agonist, with anEC50of 0.11 μM. LSP4-2022 inhibits neurotransmission in cerebellar slices from wild-type but notmGlu4receptor-knockout mice. LSP4-2022 shows pro-depressant activity[1][2]. |
| IC50& Target | mGluR4 0.11 ± 0.0 μM (EC50) | mGluR7 11.6 ± 1.9 μM (EC50) | mGluR8 29.2 ± 4.2 μM (EC50) |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
