DFMTI

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DFMTI

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

864864-86-8

MK5435

DFMTI能够完全阻止rmGlu1 L757V谷氨酸反应。

生物活性

DFMTI can completely block the rmGlu1 L757V glutamate response. In vitro: DFMTI can completely block the rmGlu1 L757V glutamate response, although significantly higher concentrations were required to induce blockade. In vivo: DFMTI is efficacious in disrupting prepulse inhibition when dosed orally in rats. DFMTI exhibits a moderate decrease in human potency of approximately 3-fold when compared to rat, exemplified by DFMTI.

IC₅₀& Target

mGluR1

分子量

368.38

性状

Solid

Formula

C₂₀H₁₈F₂N₄O

CAS 号

864864-86-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 25 mg/mL(67.86 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.7146 mL	13.5729 mL	27.1459 mL
5 mM	0.5429 mL	2.7146 mL	5.4292 mL
10 mM	0.2715 mL	1.3573 mL	2.7146 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。