LY487379 hydrochloride

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

353229-59-1

LY487379 hydrochloride 是一种选择性人mGluR2正变构调节剂 (PAM)。LY487379 hydrochloride 增强谷氨酸刺激[³⁵S]GTPγS 与EC₅₀值分别为 1.7 μM 和 >10 μM 的 mGlu2 和 mGlu3 受体的结合。LY487379 hydrochlorid 可促进大鼠认知灵活性，促进行为抑制。LY487379 hydrochlorid 可用于精神分裂症研究。

生物活性	LY487379 hydrochloride is a selectivehumanmGluR2positive allosteric modulator (PAM). LY487379 hydrochloride potentiates glutamate-stimulated [³⁵S]GTPγS binding withEC₅₀values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 hydrochloride promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 hydrochloride can be used for schizophrenia research^[2].
体内研究 (In Vivo)	LY487379 hydrochloride (intraperitoneal injection; 30 mg/kg; injected 30 min before the test) requires significantly fewer trials to criterion during the ED phase of the ASST in attentional set-shifting task in male Sprague-Dawley rats. But there has no significant drug effect during any other discrimination stage^[1]. LY487379 hydrochloride (intraperitoneal injection; 10-30 mg/kg) induces an increase in microdialysate norepinephrine levels; the dose-effect resembled a bell-shape relationship increased. And it dose-dependently increases extracellular serotonin levels in the medial prefrontal cortex in male Sprague-Dawley rats^[1].
分子量	488.91
Formula	C₂₁H₂₀ClF₃N₂O₄S
CAS 号	353229-59-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.