VU0469650

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VU0469650

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1443748-47-7

VU0469650 是一种有效的、选择性的、穿透 CNS 的mGlu₁受体的反向变构调节剂，其IC₅₀为99 nM。

生物活性

VU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator ofmGlu₁receptor, with anIC₅₀of 99 nM^[1].

IC₅₀& Target

mGluR 1

99 nM (IC₅₀)

体内研究
(In Vivo)

VU0469650 (male Sprague-Dawley rats, 0.2 mg/kg, IV, once) exhibits moderate to high clearance, a moderate volume of distribution, and a half-life of approximately 1 hour^[1].
VU0469650 (male Sprague-Dawley rats, 10 mg/kg, IP, once) shows an excellent selectivity profile and good exposure in both plasma and brain samples^[1].

分子量

364.48

Formula

C₂₂H₂₈N₄O

CAS 号

1443748-47-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.