AZD 2066 hydrate

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AZD 2066 hydrate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装:	5mg
市场价:	5850元

AZD 2066 hydrate 是一种选择性的，具有口服活性和可透过血脑屏障的mGluR5的拮抗剂。AZD 2066 hydrate 具有抗伤害作用。

生物活性

AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist ofmGluR5. AZD 2066 hydrate has antinociception effects^[1].

IC₅₀& Target^[1]

mGluR5

体外研究
(In Vitro)

AZD 2066 (1-10 μM) inhibits Ca²⁺response, with IC₅₀s of 27.2±9.1, 3.56±0.52, 96.2±17.8, and 380±78.0 nM in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures respectively^[2].
AZD 2066 (1-10 μM) inhibits the oscillatory Ca²⁺response which induced by bath application of DHPG, and blocks either DHPG or Quis effects in mGlu5/HEK cells^[2].
AZD 2066 (1-10 μM) has less effective in striatal neurons^[2].

体内研究
(In Vivo)

AZD 2066 (0.03-30 mg/kg; p.o.) shows discriminative effects in rats^[1].

Animal Model:	Male Wistar rats (weighing 240-250 g)^[1]
Dosage:	0.03, 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration:	P.o. (60 minutes after administration)
Result:	Caused full and dose-dependent AZD9272-appropriate responding.

Clinical Trial

分子量

386.33

性状

Solid

Formula

C₁₉H₁₆ClN₅O₂.1/4H₂O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month