VU0155041 sodium

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VU0155041 sodium

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1259372-69-4

VU0155041 sodium 是一种有效，选择性的mGluR4混合变构激动剂/正变构调节剂 (PAM)，对人和大鼠 mGluR4 的EC₅₀值分别为 798 nM 和 693 nM。VU0155041 sodium 有潜力用于帕金森病的研究。

生物活性

VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) ofmGluR4, withEC₅₀s of 798 nM and 693 nM for human and ratmGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD)^[1].

IC₅₀& Target^[1]

mGluR4

693 nM (EC₅₀)

体外研究
(In Vitro)

VU0155041 (10 μM) does not affect NMDA receptor currents in striatal medium spiny neurons^[1].

体内研究
(In Vivo)

VU0155041 (31 nmol, 93 nmol; i.c.v.) reverses catalepsy induced by the dopamine D2 receptor antagonist Haloperidol (1.5 mg/kg, i.p.) in rats^[1].
VU0155041 (93 nmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480) -induced akinesia in rats^[1].

Animal Model:	Third ventricle cannulated (TVC) Male Sprague-Dawley rats (225-255 g)^[1]
Dosage:	31, 93 nmol
Administration:	I.c.v. injection after the the 1.5 mg/kg of haloperidol treatment 2 h
Result:	Decreased the cataleptic effects of haloperidol, and the effects still presented 30 min after infusion.

分子量

338.16

Formula

C₁₄H₁₄Cl₂NNaO₃

CAS 号

1259372-69-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.