cis-ACPD

立即咨询

cis-ACPD

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

477331-06-9

cis-ACPD 是一种有效的NMDA受体激动剂，IC₅₀值为 3.3 μM。同时也是一种选择性的group II mGluR激动剂，对mGluR2和mGluR4的EC₅₀值分别为 13 μM 和 50 μM。

生物活性

cis-ACPD is a potent agonist ofNMDA receptor, with anIC₅₀of 3.3 μM. cis-ACPD is also a selective agonist ofgroup IImGluR, withEC₅₀s of 13 μM and 50 μM formGluR2andmGluR4, respectively^[1]^[2].

IC₅₀& Target^[1]^[2]

NMDA

3.3 μM (IC₅₀)

mGluR2

13 μM (EC₅₀)

mGluR4

50 μM (EC₅₀)

体外研究
(In Vitro)

cis-ACPD is a selective group II mGluR agonist, with EC₅₀s of 13, 50, >300 and >300 μM for mGluR2, mGluR4, mGluR1 and mGluR5, respectively^[2].
cis-ACPD (1-1000 μM; 60 min) stimulates hydrolysis of³H-phosphoinositide^[1].

体内研究
(In Vivo)

cis-ACPD (1-1000 mg/kg; i.p.) produces dose-related convulsions in rats^[1].

分子量

173.17

Formula

C₇H₁₁NO₄

CAS 号

477331-06-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.