[Glp5,(Me)Phe8,Sar9] Substance P(5-11)

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CAS NO:

77128-69-9

DiMe-C7

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) 是一种 Substance P (HY-P0201) 类似物，在大鼠大脑中对神经激肽 1 受体 (NK1R) 的作用与 Substance P (HY-P0201) 大致相等，但作用时间大大延长。[Glp5,(Me)Phe8,Sar9] Substance P (5-11) 能选择性地激活大鼠大脑间脑和中脑皮层的多巴胺代谢。[Glp5,(Me)Phe8,Sar9] Substance P (5-11) 还可增加大鼠运动活性，诱导可卡因寻求行为的恢复。

生物活性

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is aSubstance P(HY-P0201) analogue that has approximately the same effects asSubstance P(HY-P0201) onneurokinin 1 receptor(NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of cocaine-seeking behavior in rats^[1]^[2]^[3].

体内研究
(In Vivo)

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (2 μg/side; inject into the ventral tegmental area; single) 选择性地激活大鼠大脑间脑和中脑皮层的多巴胺代谢^[1]。
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (0.5, 1.5, 3 μg/side; inject into the ventral tegmental area; single) 增加大鼠运动活性，诱导可卡因寻求行为的恢复^[2]。

Animal Model:	Male Sprague-Dawley rats (300-350 g)^[1].
Dosage:	2 μg/side
Administration:	Inject into the ventral tegmental area; single
Result:	Selectively activated mesolimbic and mesocortical dopamine metabolism.

Animal Model:	Male Wistar rats (300-350 g)^[2].
Dosage:	0.5, 1.5, 3 μg/side
Administration:	Inject into the ventral tegmental area; single
Result:	Significantly increased locomotor activity when at 3 μg/side.

分子量

880.06

Formula

C₄₃H₆₁N₉O₉S

CAS 号

77128-69-9

Sequence

pGlu-Gln-Phe-N-Methyl-Phe-Sar-Leu-Met-NH2

Sequence Shortening

pGlp-QF(-Me)F-Sar-LM-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.