Fosaprepitant

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Fosaprepitant

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

172673-20-0

福沙吡坦
L-758298

Fosaprepitant (L-758298) 是 Aprepitant (HY-10052) 的前药。Fosaprepitant 是一种神经激肽-1 受体 (neurokinin-1 receptor) 拮抗剂，被开发用于预防化疗引起的恶心呕吐 (CINV)。

生物活性

Fosaprepitant (L-785298) is a prodrug of Aprepitant (HY-10052). Fosaprepitant is aneurokinin-1 receptorantagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV)^[1].

IC₅₀& Target

Neurokinin-1 receptor^[1]

体内研究
(In Vivo)

Fosaprepitant (30 mg/kg; i.p.; daily; for 7 days) attenuates tolerance to morphine and increases the antinociceptive effect in in rats^[1].

Animal Model:	Sprague-Dawley rats^[1]
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection, daily, for 7 days
Result:	Increased the antinociceptive effect of morphine compared to control group.

Clinical Trial

分子量

614.41

Formula

C₂₃H₂₂F₇N₄O₆P

CAS 号

172673-20-0

中文名称

福沙吡坦

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.