RTI-118

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RTI-118

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

847554-50-1

RTI-118 是新型的小分子神经肽 S 受体(NPSR) 拮抗剂。 RTI-118 可以缓解药物成瘾，如选择性地减少可卡因的作用。

生物活性

RTI-118 is a novel small-moleculeneuropeptide S receptor (NPSR)antagonist. RTI-118 can relieve drug addiction including selectively decrease cocaine self-administration^[1].

体外研究
(In Vitro)

RTI-118 (109 nM) has a reduction in antagonist potency at the NPS 107I variant^[2].

体内研究
(In Vivo)

RTI-118 (5-30 mg/kg, intraperitoneal injection; pre-30 minutes) is well tolerated in rats with no significant outward signs of aversion, sedation or toxicity, it also produces a dose-related decrease in cocaine and food self-administration; however these effects are selective for cocaine at lower doses (10 and 20 mg/kg)^[1].

Animal Model:	Rat^[1]
Dosage:	5 mg/kg; 10 mg/kg; 20 mg/kg; 30 mg/kg
Administration:	Intraperitoneal injection; pre-treatment 30 minutes; 5-30 mg/kg
Result:	The effects on the reinstatement of extinguished cocaine-seeking behavior are restricted to doses of 20 mg/kg or less.

分子量

448.56

Formula

C₂₆H₃₂N₄O₃

CAS 号

847554-50-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.