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[D-Trp34]-Neuropeptide Y TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

[D-Trp34]-Neuropeptide Y TFA 是有效的,选择性神经肽 Y (NPY)Y5受体激动剂。[D-Trp34]-Neuropeptide Y TFA 在 NPY Y1,Y2,Y4和 y6受体上的效力明显较低。[D-Trp34]-Neuropeptide Y TFA 明显增加大鼠的食物摄入量。
生物活性

[D-Trp34]-Neuropeptide Y TFA is a potent and selectiveneuropeptide Y (NPY) Y5receptoragonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats[1][2].

IC50& Target[1]

NPY Y5receptor

 

体外研究
(In Vitro)

[D-Trp34]-Neuropeptide Y TFA has pKivalues of 6.49, 5.43, 7.08, 7.53, 6.55, 5.95, 6.85, 7.41 for hY1, hY2, hY4, hY5, rY1, rY2, rY4, rY5in CHO cells. [D-Trp34]-Neuropeptide Y TFA has pEC50values of 6.44,<6, 6.28,7.82 for rY1, rY2in CHO cells and rY4, rY5in HEK-293 cells[1].

体内研究
(In Vivo)

[D-Trp34]-Neuropeptide Y TFA (0, 8 and 16 μg/rat; I.C.V) stimulats food intake to the same extent in both lean and obese rats 1 h after injection at a dose of 16 μg in male Zucker rats[2].

分子量

2466.76

Formula

C112H171F3N34O26

Sequence Shortening

YPSKPDNPGEDAPAEDLARYYSALRHYINLITR-{D-Trp}-RY-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

 ContentsAssign value
Acidic amino acidAsp (D), Glu (E), and the C-terminal -COOH.-1
Basic amino acidArg (R), Lys (K), His (H), and the N-terminal -NH2+1
Neutral amino acidGly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)0

3.  Recommended solution:

Overall charge of peptideDetails
Negative (<0)1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
 
 
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