生物活性 | [D-Trp34]-Neuropeptide Y TFA is a potent and selectiveneuropeptide Y (NPY) Y5receptoragonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats[1][2]. | ||||||||||||||||||||
IC50& Target[1] |
| ||||||||||||||||||||
体外研究 (In Vitro) | [D-Trp34]-Neuropeptide Y TFA has pKivalues of 6.49, 5.43, 7.08, 7.53, 6.55, 5.95, 6.85, 7.41 for hY1, hY2, hY4, hY5, rY1, rY2, rY4, rY5in CHO cells. [D-Trp34]-Neuropeptide Y TFA has pEC50values of 6.44,<6, 6.28,7.82 for rY1, rY2in CHO cells and rY4, rY5in HEK-293 cells[1]. | ||||||||||||||||||||
体内研究 (In Vivo) | [D-Trp34]-Neuropeptide Y TFA (0, 8 and 16 μg/rat; I.C.V) stimulats food intake to the same extent in both lean and obese rats 1 h after injection at a dose of 16 μg in male Zucker rats[2]. | ||||||||||||||||||||
分子量 | 2466.76 | ||||||||||||||||||||
Formula | C112H171F3N34O26 | ||||||||||||||||||||
Sequence Shortening | YPSKPDNPGEDAPAEDLARYYSALRHYINLITR-{D-Trp}-RY-NH2 | ||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. | ||||||||||||||||||||
Solvent & Solubility | In Vitro: H2O Peptide Solubility and Storage Guidelines: 1. Calculate the length of the peptide. 2. Calculate the overall charge of the entire peptide according to the following table:
3. Recommended solution:
|
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024 |