Galantide, a non-specificgalaninreceptorantagonist, is a peptide consisting of fragments ofgalaninand substance P. Galantide recognizes two classes ofgalaninbinding sites (K_D<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide dose dependently (IC₅₀=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-inducedinsulinsecretion from mouse pancreatic islets. Galantide appears to bind to a single population of SP receptors (K_D~40 nM)^[1][2][3].

Galantide do not activate the K⁺conductance but produces a concentration-dependent antagonism (IC₅₀=4 nM) of the galanin-induced increase in K⁺conductance. Galantide acts like galanin and inhibits the voltage-dependent Ba2+ current (IBa). The inhibition of IBa also is concentration dependent (IC₅₀=16 nM) and the maximum inhibition produced by galantide is approximately 40%^[3].

Intracerebroventricular injection of galanin (5 micrograms/rat) inhibited sexual behavior in experienced male rats--without producing any other locomotor or behavioral deficit-, injection of the galanin antagonist, galantide, by the same route (1 or 2 micrograms/rat) stimulated sexual behavior (improving arousal, motivation and performance indexes) and antagonized the effect of galanin^[2]. Galantide ameliorates mild acute pancreatitis (AP). Galantide significantly reduces AP-induced hyperenzymemia by 41–49%^[3]. Galantide has been found to improve social memory in 'socialrecognition' test when i.c.v. administered at doses varying from 6-6000 nM^[4].

2199.53

Solid

C₁₀₄H₁₅₁N₂₅O₂₆S

138579-66-5

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

GWTLNSAGYLLGPQQFFGLM-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)