LY2940094 tartrate

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LY2940094 tartrate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1307245-87-9

BTRX-246040 tartrate

LY2940094 (BTRX-246040) tartrate 是一种高效、可透过大脑的、选择性、口服的NOP受体拮抗剂，具有高亲和力 (K_i=0.105 nM) 和拮抗作用 (K_b=0.166 nM)。LY2940094 tartrate 可减少动物模型中的乙醇自我给药和寻求乙醇。

生物活性

LY2940094 (BTRX-246040) tartrate is a potent, brain penetrant, selective and orally available N/OFQ peptide (NOP) receptor antagonist with high affinity (K_i=0.105 nM) and antagonist potency (K_b=0.166 nM). LY2940094 tartrate reduces Ethanol self-administration and Ethanol seeking in animal models^[1].

IC₅₀& Target

Ki: 0.105 nM (NOP receptor)^[1]
Kb: 0.166 nM (NOP receptor)^[1]

体内研究
(In Vivo)

LY2940094 (3, 10, or 30 mg/kg; orally daily for 4 days) dose-dependently reduces homecage ethanol self-administration in Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, without affecting food/water intake or locomotor activity^[1].

Animal Model:	Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)^[1]
Dosage:	3, 10, or 30 mg/kg
Administration:	P.o.; daily for 4 days
Result:	Reduced homecage ethanol self-administration.

Clinical Trial

分子量

631.05

Formula

C₂₆H₂₉ClF₂N₄O₈S

CAS 号

1307245-87-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.