YNT-185 dihydrochloride

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CAS NO:

1804978-82-2

YNT-185 dihydrochloride 是一中非肽类的，选择性食欲素 2 型受体(OX2R)激动剂，对 OX2R 和 OX1R 的EC₅₀分别为 0.028 和 2.75 μM。YNT-185 dihydrochloride 改善小鼠模型的发作性瘫痪症状。

生物活性

YNT-185 dihydrochloride is a nonpeptide, selectiveorexin type-2 receptor (OX2R)agonist, withEC₅₀s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models^[1]^[2].

IC₅₀& Target^[1]

OX₂Receptor

0.028 μM (EC₅₀)

OX₁Receptor

2.75 μM (EC₅₀)

体内研究
(In Vivo)

YNT-185 dihydrochloride (20-40 mg/kg; i.p.) increases wakefulness in mice^[2].
YNT-185 dihydrochloride (300 nmol; i.c.v.) significantly increases wake time for 3 hours in a dose-dependent manner, accompanied by a decrease in NREM sleep time, in wild-type mice but not in OXRDKO mice^[2].

Animal Model:	Male wild-type C57BL/6J mice^[2]
Dosage:	20, 40 mg/kg
Administration:	I.p.
Result:	Wake time was also significantly increased.

分子量

688.66

性状

Solid

Formula

C₃₃H₃₉Cl₂N₅O₅S

CAS 号

1804978-82-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)