Mefenamic Acid(CI 473 CN-35355)

Molecular Weight (MW)	241.29
Formula	C15H15NO2
CAS No.	61-68-7
Storage	-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 48 mg/mL (198.9 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Other info	Chemical Name: 2-(2,3-dimethylanilino)benzoic acid InChi Key: HYYBABOKPJLUIN-UHFFFAOYSA-N InChi Code: InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/ h3-9,16H,1-2H3,(H,17,18) SMILES: c1(c(cccc1)C(=O)O)Nc1c(c(ccc1)C)C
Synonyms	CI-473; CN-35355; CI473; CN35355; CI 473; CN 35355; Mefenamic Acid; Ponstel; Parkemed; Coslan

Molecular Weight (MW)

241.29

Formula

C15H15NO2

CAS No.

61-68-7

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: 48 mg/mL (198.9 mM)

Water: <1 mg/mL

Ethanol: <1 mg/mL

Other info

Chemical Name: 2-(2,3-dimethylanilino)benzoic acid

InChi Key: HYYBABOKPJLUIN-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/ h3-9,16H,1-2H3,(H,17,18)

SMILES: c1(c(cccc1)C(=O)O)Nc1c(c(ccc1)C)C

Synonyms

CI-473; CN-35355; CI473; CN35355; CI 473; CN 35355; Mefenamic Acid; Ponstel; Parkemed; Coslan

In Vitro	In vitro activity: Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively. Mefenamic acid (0-100 μM) has cytotoxic effects on KB, Saos-2, and 1321N cells, however, U-87MG cells are resistant to Mefenamic acid. Cell Assay: Powder forms of Mefenamic acid, indometacin, aspirin, and celecoxib are dissolved in 0.1% dimethyl sulfoxide (DMSO) to achieve a concentration of 100 μM of stock solution, which is sterilized by filtration through a 0.22-μm filter and then stored at 4°C. Different concentrations (100, 50, 25, 10, and 5 μM) of the drugs (Mefenamic acid, etc.) are prepared by serial dilutions with the FCS-free medium or the medium containing 10% FCS in sterile plastic centrifuge tubes
In Vivo
Animal model
Formulation & Dosage
References	[1]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84. [2]. Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016 Sep;17(3):219-25.

In Vitro

In vitro activity: Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively. Mefenamic acid (0-100 μM) has cytotoxic effects on KB, Saos-2, and 1321N cells, however, U-87MG cells are resistant to Mefenamic acid.

Cell Assay: Powder forms of Mefenamic acid, indometacin, aspirin, and celecoxib are dissolved in 0.1% dimethyl sulfoxide (DMSO) to achieve a concentration of 100 μM of stock solution, which is sterilized by filtration through a 0.22-μm filter and then stored at 4°C. Different concentrations (100, 50, 25, 10, and 5 μM) of the drugs (Mefenamic acid, etc.) are prepared by serial dilutions with the FCS-free medium or the medium containing 10% FCS in sterile plastic centrifuge tubes

In Vivo

Animal model

Formulation & Dosage

References

[1]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84.

[2]. Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016 Sep;17(3):219-25.

CAS NO:	61-68-7
规格:	≥98%

包装	价格(元)
1g	询价
2g	询价
5g	询价
10g	询价
25g	询价
50g	询价
100g	询价