LIT-001 free base

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LIT-001 free base

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2245072-20-0

LIT-001 free base 是第一种非肽类催产素受体(OT-R)激动剂 (EC₅₀=55 nM;K_i=226 nM)。LIT-001 free base 改善孤独症小鼠模型的社交互动。

生物活性

LIT-001 free base is the first nonpeptideoxytocin receptor(OT-R)agonist (EC₅₀=55 nM;K_i=226 nM). LIT-001 free base improves social interaction in a mouse model of autism^[1].

体外研究
(In Vitro)

In vitro signaling experiments, LIT-001 free base is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only^[1].

体内研究
(In Vivo)

LIT-001 free base (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD )^[1].

Animal Model:	Oprm1^–/–mice (bred in house on a 50% 129SVPas–50% C57BL/6J hybrid background)^[1]
Dosage:	10, 20 mg/kg
Administration:	i.p.
Result:	Alleviated core symptoms in the context of ASD.

分子量

531.67

Formula

C₂₈H₃₃N₇O₂S

CAS 号

2245072-20-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.