OT antagonist 1 (Compound 4) is a potent, selectiveOxytocinantagonist with aK_iof 50 nM.

Ki: 50 nM (Oxytocin)^[1]

Oxytocin (OT) is a nonapeptide hormone that acts on the OT receptor, a seven-transmembrane (7TM) (Gq-coupled) receptor. The OT receptor has no subtypes but is related to the vasopressin receptors V_1A, V_1Band V₂. OT antagonists have therapeutic potential in a number of areas including pre-term labour: Benign Prostatic Hyperplasia and sexual dysfunction. As a result there is significant interest in the identification of potent, selective, orally bioavailable OT antagonists^[1].

390.44

C₂₂H₂₂N₄O₃

479080-38-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.