MRS2768 tetrasodium salt

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MRS2768 tetrasodium salt 是一种中等效力和选择性的P2Y2受体激动剂。MRS2768 tetrasodium salt 对心肌细胞缺血损伤具有保护作用。

生物活性

MRS2768 tetrasodium salt is a moderately potent and selectiveP2Y2 receptoragonist. MRS2768 tetrasodium salt has a protective effect on cardiomyocytes from ischemic damage in vivo and in vitro^[1]^[2].

IC₅₀& Target

P2Y2 Receptor

体外研究
(In Vitro)

MRS2768 (0.01-10000 μM; 24 hours) significantly increases the proliferation of PANC-1 cells^[1].

Cell Proliferation Assay^[1]

Cell Line:	Human pancreatic duct epithelial cells PANC-1
Concentration:	0.01, 0.1, 1, 10, 100, 1000, 10000 μM
Incubation Time:	24 hours
Result:	The effect on proliferation of PANC-1 cells was dependent on concentration (0.1 μM to 1 mM). The concentration that elicited a half-maximal response (EC₅₀) in the stimulation of proliferation was 0.8±1.7 μM. Resulted in a dose- and time-dependent increase of proliferation in PANC-1 cells

体内研究
(In Vivo)

MRS2768 (4.44 μg/kg i.v.) pretreatment reduces myocardial damage in mice. MRS2768 has a protective effect on cardiomyocytes from ischemic damage in vivo^[2].

Animal Model:	Male wild-type mice (C57BL)^[2]
Dosage:	4.44 μg/kg
Administration:	Injected i.v.; 1 h before myocardial infarct (MI)
Result:	Pretreatment reduced myocardial damage. The damage was significantly smaller in mice compare to the untreated mice (25.6±4.5% vs. 39.2±6.3%).

分子量

728.14

Formula

C₁₅H₁₆N₂Na₄O₁₈P₄

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.