MRS2179 tetrasodium hydrate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装:	5mg
市场价:	5500元

MRS2179 tetrasodium hydrate 是一种竞争性P2Y1受体拮抗剂，对火鸡 P2Y1 受体的K_b值为 102 nM，pA₂为 6.99。MRS2179 tetrasodium hydrate 对 P2Y1 的选择性高于 P2X1 (IC₅₀=1.15 μM)、P2X3 (12.9 μM)、P2X2、P2X4、P2Y2、P2Y4 和 P2Y6 受体。MRS2179 tetrasodium hydrate 抑制血小板聚集。

生物活性

MRS2179 tetrasodium hydrate is a competitiveP2Y1receptor antagonist, with aK_bof 102 nM and apA₂of 6.99 for turkeyP2Y1 receptor. MRS2179 tetrasodium hydrate is selective for P2Y1 over P2X1 (IC₅₀=1.15 μM), P2X3 (12.9 μM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors^[1]^[2]. MRS2179 tetrasodium hydrate inhibits platelet aggregation^[3].

体内研究
(In Vivo)

MRS2179 tetrasodium hydrate (50 mg/kg; i.p.) prolongs the bleeding time^[3].

Animal Model:	CL57BLr6 mice^[3]
Dosage:	50 mg/kg
Administration:	Injection into the jugular vein of mice
Result:	The bleeding time, which reflects in vivo primary haemostasis, was significantly prolonged in MRS2179-treated mice, 30 s after injection of MRS2179.

分子量

576.21

性状

Solid

Formula

C₁₁H₁₃N₅O₉P₂Na₄.3?H₂O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)