Licarin A

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Licarin A

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Licarin A图片

CAS NO:

51020-86-1

(+)-Licarin A

Licarin A ((+)-Licarin A) 显着降低二硝基苯肼-人血清白蛋白 (DNP-HSA) 刺激的 RBL-2H3 细胞。具有抗过敏作用。Licarin A 降低TNF-α和PGD2产生，和COX-2表达。

生物活性	Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC₅₀=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reducesTNF-αandPGD2production, andCOX-2expression^[1].
体外研究 (In Vitro)	Licarin A is found in plants such asAristolochia taliscana,Machilus thunbergiiandMyristica fragrans, which are used as spices and in folk medicines for nervous and digestive disorders. Licarin A also exhibits anti-inflammatory effects^[1]. Licarin A (5-20 μM) reduces TNF-α and prostaglandin D2 (PGD2) secretion via the inhibition of PKCα/βII and p38 MAPK pathways. Licarin A treatment tends to reduce phosphorylated PKCα/βII and p38 MAPK protein levels^[1].
分子量	326.39
性状	Solid
Formula	C₂₀H₂₂O₄
CAS 号	51020-86-1
中文名称	里卡灵 A
结构分类	Phenylpropanoids Simple Phenylpropanols Phenols Monophenols
来源	Plants Saururaceae Saururus chinensis(Lour.) Baill.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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