2-Furoyl-LIGRLO-amide TFA

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包装与价格：

包装	价格(元)
1mg	询价
5mg	询价
10mg	询价

2-Furoyl-LIGRLO-amide TFA 是一种有效的选择性蛋白酶激活受体2 (PAR2) 激动剂，其pD₂值为 7.0。

生物活性

2-Furoyl-LIGRLO-amide TFA is a potent and selectiveproteinase-activated receptor 2 (PAR2)agonist with apD₂value of 7.0^[1]^[2]..

IC₅₀& Target

Proteinase-activated receptor 2 (PAR2)^[1]

体外研究
(In Vitro)

2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH₂) is equally effective to and 10 to 25 times more potent than SLIGRLNH₂for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively^[1].
In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH₂) is 10 to 300 times more potent than SLIGRL-NH₂. Unlike trans-cinnamoyl-LIGRLO-NH₂, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries^[1].

体内研究
(In Vivo)

Furoyl-LIGRLO-amide TFA (injected intradermally at the nape of the neck; 10 μg; pre-injected) exhibits fewer scratches in response to 2-Furoyl-LIGRLO-amide but not to histamine in Trpv3^-/-mice. But it decreases significantly the number of scratches in WT mice^[3].

Animal Model:	Adult male (2/3-month-old) Trpv3^-/-and WT mice^[2]
Dosage:	10 μg
Administration:	Injected intradermally at the nape of the neck
Result:	Was involved in PAR2- induced acute itch.

分子量

891.98

Formula

C₃₈H₆₄F₃N₁₁O₁₀

Sequence

{Fur-2-oyl}-Leu-Ile-Gly-Arg-Leu-{Orn}-NH2

Sequence Shortening

{Fur-2-oyl}-LIGRL-{Orn}-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.