UDM-001651 是一种有效选择性的、口服生物可利用的蛋白酶激活受体 4(PAR4)拮抗剂 (IC50=4 nM；Kd=1.4 nM)。UDM-001651 在 γ-凝血酶诱导的富含血小板的血浆聚集测定 (γ-Thr PRP) 中显示抗血小板活性 (IC50=25 nM)。
| 生物活性 | UDM-001651 is a potent, selective, and orally bioavailableprotease-activated receptor4 (PAR4)antagonist (IC50=4 nM;Kd=1.4 nM). UDM-001651 shows antiplatelet potency (IC50=25 nM) in a γ-thrombin-induced platelet-rich plasma aggregation assay (γ-Thr PRP)[1]. |
| IC50& Target | IC50: 4 nM (PAR4)[1]
Kd: 1.4 nM (PAR4)[1] |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
