G12Si-1 是一种具有选择性的K-Ras(G12S)共价抑制剂，能抑制K-Ras(G12S)致癌信号的传导。G12Si-1 在突变的丝氨酸残基上具有较好的共价结合K-Ras(G12S)的能力。G12Si-1 也可通过阻止 Sos 催化的交换，并降低 EDTA 促进的交换速率来影响K-Ras的核苷酸循环。
| 生物活性 | G12Si-1 is a selectiveK-Ras(G12S)covalent inhibitor, which can inhibit oncogenic signaling ofK-Ras(G12S). G12Si-1 shows good ability to covalently engage recombinantK-Ras(G12S)at the mutant serine residue. G12Si-1 can also affect nucleotide cycling ofK-Rasby blocking Sos-catalyzed exchange and decreasing the rate of EDTA promoted exchange[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
