KRAS G12D inhibitor 16

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CAS NO:

2648221-12-7

KRAS G12D inhibitor 16 是一种KRAS G12D抑制剂。KRAS G12D inhibitor 16 对 KRAS G12D 和 KRAS G12D 突变具有抑制活性，IC₅₀值分别为 0.7 nM 和 0.35 μM。KRAS G12D inhibitor 16 可用于多种恶性肿瘤的研究，如胰腺导管腺癌（PDAC）、结肠直肠癌（CRC）、非小细胞肺癌（NSCLC）。

生物活性

KRAS G12D inhibitor 16 is aKRAS G12Dinhibitor. KRAS G12D inhibitor 16 has inhibitory activity against KRAS G12D and KRAS G12D mutation withIC₅₀value of 0.7 nM and 0.35 μM, respectively. KRAS G12D inhibitor 16 can be used for the research of many malignant tumor, such as pancreatic ductal adenocarcinomas (PDAC), colon and rectal carcinomas (CRC), non-small cell lung carcinomas (NSCLC)^[1].

IC₅₀& Target

KRas G12D

0.7 nM (IC₅₀)

体外研究
(In Vitro)

KRAS G12D inhibitor 16 has inhibitory activity for G12 with an IC₅₀value of 0.7 nM^[1].
KRAS G12D inhibitor 16 shows growth inhibition activity KRAS-G12D mutant cell line (A-427) with an IC₅₀value of 0.35 μM^[1].

分子量

682.59

Formula

C₃₂H₃₉IN₆O₃

CAS 号

2648221-12-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.