KRAS G12C inhibitor 47

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CAS NO:

2253119-24-1

KRAS G12C inhibitor 47 (compound 8-1-1) 是一种有效的KRAS G12C抑制剂，IC₅₀为 0.172 μM。KRAS G12C inhibitor 47 在 MIA PaCA-2，A549 细胞中显示出 p-ERK 抑制活性，IC₅₀s 分别为 0.046，69.8 μM。KRAS G12C inhibitor 47 具有研究胰腺癌，结直肠癌和肺癌的潜力。

生物活性

KRAS G12C inhibitor 47 (compound 8-1-1) is a potentKRAS G12Cinhibitor with anIC₅₀of 0.172 μM. KRAS G12C inhibitor 47 shows p-ERK inhibition activities with IC₅₀s of 0.046, 69.8 μM in MIA PaCA-2, A549 cells, respectively. KRAS G12C inhibitor 47 has the potential for the research of pancreatic, colorectal, and lung cancers^[1].

IC₅₀& Target^[1]

KRas G12C

0.172 μM (IC₅₀)

分子量

547.02

Formula

C₃₀H₂₈ClFN₄O₃

CAS 号

2253119-24-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.