KRAS G12C inhibitor 48

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KRAS G12C inhibitor 48 (compound 6e) 是一种有效的KRAS G12C抑制剂，IC₅₀为 639.91 nM。 KRAS G12C inhibitor 48 (0-50 μM) 具有抗增殖活性，对 H358，H23，A549 细胞的 IC₅₀s 分别为 0.796，6.33，16.14 μM.

生物活性

KRAS G12C inhibitor 48 (compound 6e) is a potentKRAS G12Cinhibitor with anIC₅₀of 639.91 nM. KRAS G12C inhibitor 48 (0-50 μM) shows anti-proliferative activity with IC₅₀s of 0.796, 6.33, 16.14 μM for H358, H23, A549 cells, respectively^[1].

IC₅₀& Target

KRas G12C

639.91 nM (IC₅₀)

分子量

651.20

Formula

C₃₆H₃₉ClN₈O₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.