d[Cha4]-AVP TFA is a potent and selectivevasopressin (AVP) V1b receptoragonist with aK_iof 1.2 nM forhuman V1b receptor. d[Cha4]-AVP TFA shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors^[1][2].

Ki: 1.2 nM (vasopressin V1B receptor), 151 nM (vasopressin V1A receptor), 240 nM (Oxytocin receptor), 750 nM (vasopressin V2 receptor)

d[Cha4]-AVP binds to hV1b receptors and human oxytocin receptors with pK_ivalues of 9.68 and 7.68, respectively^[2].
d[Cha4]-AVP stimulates [Ca²⁺]_iincrease in hV1b-CHO cells with a pEC₅₀value of 10.05. d[Cha4]-AVP shows pEC₅₀values of 6.53 and 5.92 at hV1a and hV2 receptors, respectively, and behaved as a weak antagonist at hOT receptors (pKB=6.31)^[2].

1208.33

C₅₂H₇₂F₃N₁₃O₁₃S₂

{Mpa}-Tyr-Phe-{Cha}-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge:Mpa1-Cys6)

{Mpa}YF{Cha}NCPRG-NH2 (Disulfide bridge:Mpa1-Cys6)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.