Antagonist G

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Antagonist G

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

115150-59-9

Antagonist G 是有效的后叶加压素 (vasopressin) 的拮抗剂。Antagonist G 也是弱的 GRP 和缓激肽的弱拮抗剂。Antagonist G 可诱导 AG-1 的转录，是癌细胞对化疗增敏。

生物活性

Antagonist G is a potentvasopressinantagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G inducesAP-1transcription and sensitizes cells to chemotherapy^[1]^[2].

体外研究
(In Vitro)

Antagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells^[2].
Antagonist G activates JNK1 in SCLC cells^[2].
Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%^[2].

Cell Viability Assay^[2]

Cell Line:	SCLC cell lines NCI-H69, NCI-H510 and CHO-K1 cells.
Concentration:	0-100 μM.
Incubation Time:	24 h.
Result:	Inhibited cell growh.

分子量

951.19

性状

Solid

Formula

C₄₉H₆₆N₁₂O₆S

CAS 号

115150-59-9

Sequence Shortening

RW-{Me-Phe}-WLM-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

H₂O : 50 mg/mL(52.57 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.0513 mL	5.2566 mL	10.5131 mL
5 mM	0.2103 mL	1.0513 mL	2.1026 mL
10 mM	0.1051 mL	0.5257 mL	1.0513 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。