E7766 diammonium salt is a macrocycle-bridgedSTINGagonist with aK_dof 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities^[1].

E7766 diammonium salt inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC₅₀values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively^[1].

In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 diammonium salt in the subcutaneous tumor. E7766 diammonium salt is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model^[1].

780.66

Solid

C₂₄H₃₂F₂N₁₂O₈P₂S₂

2242635-03-4

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

H₂O : 45 mg/mL(57.64 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。