Pepinh-TRIF TFA

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Pepinh-TRIF TFA

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

Pepinh-TRIF (TFA) 是一种 30 aa 肽，通过干扰 TLR-TRIF 的相互作用 (TLR-TRIF interaction) 来阻断 TRIF 信号。

生物活性

Pepinh-TRIF (TFA) is a 30 aa peptide that blocks TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling by interfering withTLR-TRIF interaction^[1].

体外研究
(In Vitro)

Pepinh-TRIF (40 μM, 6 hours) blocks the expression and production of IL-33 stimulated by polyI:C or flagellin, and also greatly suppresses the stimulated IκB-α phosphorylation and degradation in HCECs^[1].
Pepinh-TRIF (40 μM, 6 hours) suppresses NF-κB activation with p65 protein nuclear translocation^[1].

Western Blot Analysis^[1]

Cell Line:	HCECs
Concentration:	40 μM
Incubation Time:	6 hours
Result:	Blocked NF-κB activation with p65 nuclear translocation.

分子量

4016.63

性状

Solid

Formula

C₁₈₀H₂₇₉F₃N₅₈O₄₀S₂

Sequence Shortening

RQIKIWFQNRRMKWKKFCEEFQVPGRGELH-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据

In Vitro:

H₂O : 50 mg/mL(12.45 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	0.2490 mL	1.2448 mL	2.4896 mL
5 mM	0.0498 mL	0.2490 mL	0.4979 mL
10 mM	0.0249 mL	0.1245 mL	0.2490 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。