ODN 24888 是一种鸟嘌呤修饰的抑制性寡核苷酸 (INH-ODN)，对TLR7/TLR9介导的信号通路表现出强烈的抑制作用。ODN 24888 损害 IFN-α 水平和 NF-κB 激活，抑制 IL-6 的释放。ODN 24888 参与免疫和炎症应答，可作为疫苗佐剂使用。
| 生物活性 | ODN 24888 is an guanine-modified inhibitoryoligonucleotides(INH-ODN), shows potent inhibition onTLR7/TLR9-mediated signaling. ODN 24888 impairs IFN-α level andNF-κBactivation, inhibitsIL-6release. ODN 24888 involves in immune and inflammatory responses, can be used as a vaccine adjuvant[1][2]. |
| IC50& Target | |
| CAS 号 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
