Pam3CSK4-Biotin

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Pam3CSK4-Biotin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

Pam3Cys-Ser-(Lys)4-Biotin

Pam3CSK4-Biotin 是生物素化的 Pam3CSK4。Pam3CSK4-Biotin 是 Toll 样受体 1/2 (TLR1/2) 激动剂。

生物活性

Pam3CSK4-Biotin is biotinylated Pam3CSK4. Pam3CSK4-Biotin is aToll-like receptor1/2 (TLR1/2) agonist^[1].

IC₅₀& Target

TLR1

TLR2

体外研究
(In Vitro)

Pam3CSK4-Biotin (100 ng/mL) induces NF-κB activation from endosomal compartments^[1].

分子量

1962.85

Formula

C₁₀₃H₁₉₂N₁₄O₁₇S₂

Sequence Shortening

Pam3C-SKKKK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.