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Monophosphoryl lipid A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Monophosphoryl lipid A图片
CAS NO:1246298-63-4
包装:1mg

Glucopyranosyl lipid A
Monophosphoryl lipid A (Glucopyranosyl lipid A) 是一种toll-like receptor 4激动剂。Monophosphoryl lipid A 来源于非致病性沙门氏菌的细胞壁。Monophosphoryl lipid A 可用于免疫和疫苗研究。
生物活性

Monophosphoryl lipid A (Glucopyranosyl lipid A) is atoll-like receptor 4agonist. Monophosphoryl lipid A is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A can be used for the research of immunization and vaccine[1].

IC50& Target[1]

TLR4

 

体外研究
(In Vitro)

Monophosphoryl lipid A (100 μg/ml, 2 hours; dendritic cells) induces NF-κB activation and modulates TLR2[2].
Monophosphoryl lipid A (5~100 μg/ml, 24 hours; dendritic cells) induces IL-12 production by human[2].
Increasing the amount of Monophosphoryl lipid A (from 0.1 to 1 μg), the percentage of matured BMDCs also increased[1]. Monophosphoryl lipid A up-regulates dendritic cells surface markers. Monophosphoryl lipid A enhances T cell responses. Monophosphoryl lipid A (CD4 T cells) increases calcium mobilization of activated T cells[2].

Western Blot Analysis[2]

Cell Line:Dendritic cells
Concentration:100 μg/ml
Incubation Time:2 hours
Result:Induced NF-κB activation and modulated TLR2.
体内研究
(In Vivo)

The generated Monophosphoryl lipid A has been shown to activate APC and to enhance the generation of both Th1- and Th2-specific immune response in mice[2].

Clinical Trial
分子量

1763.47

性状

Solid

Formula

C96H184N3O22P

CAS 号

1246298-63-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

 
 
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