MAPK-IN-1

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MAPK-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2470587-69-8

MAPK-IN-1 (Compound 2) 是一种MAPK信号通路抑制剂。MAPK-IN-1 抑制AChE，IC₅₀为 23.84 μM。MAPK-IN-1 具有抗神经炎症和神经保护作用，可用于阿尔兹海默症的研究。

生物活性

MAPK-IN-1 (Compound 2) is aMAPK signaling pathwayinhibitor. MAPK-IN-1 exhibitsAChEinhibitory activity with anIC₅₀of 23.84 μM. MAPK-IN-1 shows anti-neuroinflammatory and neuroprotective activity and can be used for Alzheimer's disease research^[1].

IC₅₀& Target

TLR4

体外研究
(In Vitro)

MAPK-IN-1 (Compound 2) inhibits NO, IL-1β, IL-6, and TNF-α release in BV-2 cells withIC₅₀values of 0.49 ± 0.17, 1.34 ± 0.21, 9.17 ± 0.17 and 8.17 ± 0.23 μM, respectively^[1].
MAPK-IN-1 downregulates LPS-induced phosphorylation of JNK, ERK, and p38 in MAPK signaling pathway^[1].
MAPK-IN-1 inhibits expressions of iNOS, COX-2, and TLR4 in LPS-induced BV-2 cells^[1].

分子量

310.34

Formula

C₁₉H₁₈O₄

CAS 号

2470587-69-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.