TLR7/8 antagonist 2 (Compound 15) 是一种有效的、具有口服活性的TLR7/8激动剂，IC50值分别为 4.9 和 0.6 nM。TLR7 和 TLR8 的不适当激活与几种自身免疫性疾病有关，例如红斑狼疮。TLR7/8 antagonist 2 具有自身免疫性疾病研究的潜力。
| 生物活性 | TLR7/8 antagonist 2 (Compound 15) is a potent and orally active agonist ofTLR7/8withIC50s of 4.9 and 0.6 nM, respectively. Inappropriate activation ofTLR7andTLR8is linked to several autoimmune diseases, such as lupus erythematosus. TLR7/8 antagonist 2 has the potential for the research of autoimmune diseases[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
