Gardiquimod

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Gardiquimod

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1020412-43-4

Gardiquimod，一种咪唑啉类似物，TLR7/8激动剂。Gardiquimod 可抑制巨噬细胞和活化外周血单个核细胞 (PBMCs) 的 HIV-1 感染。当浓度低于 10 μM 时，Gardiquimod 特别激活 TLR7。

生物活性

Gardiquimod, an imidazoquinoline analog, is aTLR7/8agonist. Gardiquimod could inhibit HIV-1infectionof macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod specifically activatesTLR7when used at concentrations below 10 μM^[1]^[2].

IC₅₀& Target^[1]

TLR7

TLR8

HIV-1

体外研究
(In Vitro)

Gardiquimod (6-60 μM ) significantly inhibits cDNA synthesis by HIV-1 reverse transcriptase^[1].

体内研究
(In Vivo)

Dendritic cells (DCs) in combination with Gardiquimod (1 mg/kg per mouse; i.p.; daily for 7 days) improves the anti-tumor effects of NK cells^[2].

Animal Model:	Male athymic nude mice (Balb-nu/nu, 5 weeks old) (bearing human HepG2 liver carcinoma xenografts)^[2]
Dosage:	1 mg/kg per mouse
Administration:	i.p.; daily for 7 days
Result:	Significantly suppressed the growth of human HepG2 liver carcinoma xenografts.

分子量

313.40

Formula

C₁₇H₂₃N₅O

CAS 号

1020412-43-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.