8-Bromo-ATP

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8-Bromo-ATP

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CAS NO:	23567-97-7
包装:	1mg

8-Bromoadenosine 5'-triphosphate
8-Br-ATP

8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate)，一种 ATP 类似物，是一种嘌呤能P2X receptor受体的激动剂。8-Bromo-ATP 对多发性骨髓瘤细胞具有细胞毒性，IC₅₀为 23.1 μM。

生物活性

8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate), an ATP analogue, is a purinergicP2X receptoragonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with anIC₅₀of 23.1 μM^[1]^[2]^[3].

体外研究
(In Vitro)

8-Bromo-ATP (10-50 μM; 5 days) treatment shows cytotoxic to multiple myeloma^[3].
Fluorescence measurements are made possible through the use of 8-Bromo-ATP, which selectively quenched certain tryptophan residues of the ATPase. 8-Bromo-ATP enhances the rate of dephosphorylation of native ATPase 2-3-fold when added in the absence of divalent cations^[2].

Cell Viability Assay^[3]

Cell Line:	MM 1.s cells
Concentration:	10 μM, 20 μM, 30 μM, 40 μM, 50 μM
Incubation Time:	5 days
Result:	Showed cytotoxic to multiple myeloma.

分子量

586.08

Formula

C₁₀H₁₅BrN₅O₁₃P₃

CAS 号

23567-97-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.