E-4031

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E-4031

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

113559-13-0

E-4031 是一种选择性hERG钾通道阻断剂，可用于 III 类抗心律失常研究。

生物活性

E-4031 is a selectivehERGpotassium channelblocker for use in class III anti-arrhythmic studies^[1].

体外研究
(In Vitro)

E-4031 (0.1-10 μM) significantly depolarises the maximum diastolic potential (MDP) and prolongs the action charge that depolarises MDP from -58.8+0.9 to -24.5±1.8 mV at 1 μM and from -58.2±2.1 to -19.6±1.8 mV at 10 μM in single SAN cells of New Zealand albinc rabbits^[2].
E-4031 (0.1-10 μM) can block part of the outward current during the depolarisation step as well as the tail current (I_TD) during subsequent repolarization in a dose-dependent manner, and depresses I_TDby 88 % at 10 μM in single SAN cells of New Zealand albinc rabbits^[2].

体内研究
(In Vivo)

E-4031 (i.v., 50 μg/kg) reduces the net outward current of ventricular myocytes, prolongs the QT interval and activation-recovery interval (ARI) in all left ventricular (LV) layers, and increases transmural ARI dispersion in beagles^[1].

分子量

474.44

性状

Solid

Formula

C₂₁H₂₉Cl₂N₃O₃S

CAS 号

113559-13-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : ≥ 50 mg/mL(105.39 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.1077 mL	10.5387 mL	21.0775 mL
5 mM	0.4215 mL	2.1077 mL	4.2155 mL
10 mM	0.2108 mL	1.0539 mL	2.1077 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (210.77 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。