Quinate 是一种抗心律失常剂。Quinate 是一种有效的、具有口服活性的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，也是 K+通道 (K+channel) 的有效阻断剂，其IC50值为 19.9 μM，也可诱导凋亡。Quinate 也可用作疟疾的研究。
| 生物活性 | Quinate is an antiarrhythmic agent. Quinate is a potent, orally active, selectivecytochrome P450dbinhibitor. Quinate is also aK+channelblocker with anIC50of 19.9 μM, and can induceapoptosis. Quinate can be used for malaria research[1][2][3][4]. |
体外研究
(In Vitro) | Quinate shows cytotoxicity against MES-SA cells, and induces apoptosis[4].
Cell Cytotoxicity Assay[4] | Cell Line: | MES-SA and MESSA/DX5 cells | | Concentration: | 10 μM | | Incubation Time: | 24 hours | | Result: | Showed cytotoxicity against MES-SA cells in a concentration-dependent manner. |
Apoptosis Analysis[4] | Cell Line: | MES-SA and MESSA/DX5 cells | | Concentration: | 10 μM | | Incubation Time: | 24 hours | | Result: | Increased the apoptotic portion sub-G1 DNA contents induced by paclitaxel, while paclitaxel had no effect on sub-G1 DNA contents undergoing apoptosis. |
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体内研究
(In Vivo) | Quinate shows effects on the PTZ-induced seizure threshold[5].
| Animal Model: | Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5] | | Dosage: | 10, 20, and 30 mg/kg | | Administration: | Intraperitoneal injection; 10, 20, and 30 mg/kg; once | | Result: | Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05). |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
