Pantoprazole

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Pantoprazole

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

102625-70-7

泮托拉唑
BY1023
SKF96022

Pantoprazole (BY1023) 是一种具有口服活性的，有效质子泵 (proton pump) 抑制剂 (PPI)。Pantoprazole 是一种取代的苯并咪唑，是一种有效的H⁺/K⁺-ATPase抑制剂，IC₅₀为 6.8 μM。Pantoprazo 可以改善 pH 值稳定性，并具有抗分泌，抗溃疡的作用。Pantoprazo 联合阿霉素 (Doxorubicin; HY-15142) 可显着增加肿瘤生长延迟。

生物活性

Pantoprazole (BY10232) is an orally active and potentproton pumpinhibitor (PPI)^[1]. Pantoprazole, a substituted benzimidazole, is a potentH⁺/K⁺-ATPaseinhibitor with anIC₅₀of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)^[3]^[4].

IC₅₀& Target

proton pump

体外研究
(In Vitro)

Pantoprazole (BY1023; 1-10000 μM) leads to concentration-dependent increases in endosomal pH in EMT-6 and MCF7 cells^[1].
Pantoprazole (BY10232) can block exosome release. Pantoprazole (BY10232) inhibits the activity of V-H⁺-ATPase and impaires the ability of tumour cells (melanomas, adenocarcinomas, and lymphoma cell lines) to acidify the extracellular medium^[2]

体内研究
(In Vivo)

Pantoprazole (BY1023; 200 mg/kg; IP; once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin^[1].
Pantoprazole (0.3-3 mg/kg, p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats^[4].

Animal Model:	Mice bearing MCF-7 or A431 xenografts^[1]
Dosage:	200 mg/kg
Administration:	IP; once a week for 3 weeks; alone or 2 hours before Doxorubicin (6 mg/kg i.v.)
Result:	Showed even greater growth delay of MCF-7 xenografts with Doxorubicin compared with the single-dose combination. Significantly increased tumor growth delay with a single dose with Doxorubicin. There is no effect on growth delay alone.

Clinical Trial

分子量

383.37

Formula

C₁₆H₁₅F₂N₃O₄S

CAS 号

102625-70-7

中文名称

泮托拉唑

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.