AMG8380

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AMG8380

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1642112-32-0

AMG8380 是一种具有口服活性的和低活性的 AMG8379 的对映体，可作为阴性对照。AMG8380 抑制人和小鼠电压门控钠通道NaV1.7，IC₅₀分别为 0.907、0.387 μM。AMG8380 阻断 Tetrodotoxin 敏感的通道用 IC₅₀为 2560 nM。

生物活性

AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gatedsodium channelNaV1.7withIC₅₀s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC₅₀of 2560 nM^[1].

IC₅₀& Target^[1]

hNa_v1.7

0.907 μM (IC₅₀)

mNa_v1.7

0.387 μM (IC₅₀)

体内研究
(In Vivo)

Animal Model:	C57Bl/6 male mice^[1]
Dosage:	100 mg/kg
Administration:	oral
Result:	Failed to show a statistically significant effect on scratching behavior.

分子量

543.93

Formula

C₂₅H₁₆ClF₂N₃O₅S

CAS 号

1642112-32-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.