Alvelestat (AZD9668) 是一种口服生物利用度，亲和性和选择性的中性粒细胞弹性蛋白酶 (NE) 抑制剂，其pIC50值为 7.9 nM，Ki值为 9.4 nM，Kd值为 9.5 nM。
| 生物活性 | Alvelestat (tosylate) is an orally bioavailable, affinity and selective inhibitor ofneutrophilelastase(NE)with apIC50value of 7.9 nM, aKivalue of 9.4 nM and aKdvalue of 9.5 nM[1]. |
| IC50& Target | pIC: 7.9 nM; Ki: 9.4 nM; Kd: 9.5 nM (neutrophil elastas)[1] |
体外研究
(In Vitro) | Alvelestat (20 μg/mL; 16 hours; HBE and A549 cells) treatment decreases cells death and decreases the levels of IL-1β, IL-6, and TNF-α in vitro[2].
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
