MPO-IN-5

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MPO-IN-5

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2476764-11-9

MPO-IN-5 (化合物 1) 是一种有效的、不可逆的MPO(髓过氧化物酶)抑制剂。MPO-IN-5 抑制MPO过氧化作用和hERG结合，IC₅₀值分别为 0.22 和 2.8 μM。MPO-IN-5 表现出快速的抑制动力学，酶失活率 (k_inact/K_i) 为 23000 M^–1s^–1。

生物活性	MPO-IN-5 (compound 1) is a potent, irreversibleMPO(myeloperoxidase) inhibitor. MPO-IN-5 inhibitsMPOperoxidation andhERGbinding, withIC₅₀values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (k_inact/K_i) of 23000 M^–1s^–1^[1].
IC₅₀& Target	IC₅₀: 0.22 μM (MPO peroxidation), 2.8 μM (hERG binding), 30 μM (TPO)^[1]
分子量	428.49
Formula	C₂₄H₂₄N₆O₂
CAS 号	2476764-11-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.