IDH1 Inhibitor 5

立即咨询

IDH1 Inhibitor 5

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1940128-37-9

IDH1 Inhibitor 5 (compound 2) 是IDH1（异柠檬酸脱氢酶 1）的抑制剂。IDH1 Inhibitor 5 抑制 MOG 细胞以及表达外源突变 IDH1 R132H 蛋白的野生型 IDH1 胶质瘤细胞，IC₅₀值分别为 64.4 和 34.9 nM。

生物活性

IDH1 Inhibitor5 (compound 2) is anIDH1(isocitrate dehydrogenase 1) inhibitor.IDH1 Inhibitor5 inhibits MOG cells and wild-typeIDH1glioma cells with expressing exogenous mutantIDH1R132H protein withIC₅₀s of 64.4 and 34.9 nM, respectively^[1].

IC₅₀& Target

IC50: 64.4 nM (MOG cells), 34.9 nM (wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein)^[1]

体外研究
(In Vitro)

IDH1 Inhibitor 5 (0-10 μM; 1 h) shows cellular potency in MOG cells^[1].

Cell Cytotoxicity Assay^[1]

Cell Line:	MOG cell line and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein
Concentration:	0-10 μM
Incubation Time:	1 hour
Result:	Showed cellular potency to MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC₅₀s of 64.4 and 34.9 nM, respectively.

分子量

450.57

Formula

C₂₆H₃₄N₄O₃

CAS 号

1940128-37-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.