Imeglimin

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Imeglimin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

775351-65-0

EMD 387008

Imeglimin (EMD 387008) 是一种口服降糖剂。Imeglimin 可改善胰岛素敏感性。Imeglimin 还减少活性氧 (ROS) 的产生，增加了线粒体 DNA，并改善线粒体功能。

生物活性

Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improvesinsulinsensitivity. Imeglimin also reducesreactive oxygen species(ROS) production, increases mitochondrial DNA and improvesmitochondrialfunction^[1].

IC₅₀& Target

ROS; mitochondrial function^[1]

体外研究
(In Vitro)

Preincubation with Imeglimin (10 mM for 4 h or 100 μM for 24 h) fully prevents tert-butylhydroperoxide (tBH)-induced cell death^[2].

Cell Viability Assay^[2]

Cell Line:	Human endothelial cells (HMEC-1)
Concentration:	100 μM and10 mM
Incubation Time:	100 μM for 24 h, 10 mM for 4 h
Result:	Prevention of cell death.

体内研究
(In Vivo)

Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, restores normal glucose tolerance, and improves insulin sensitivity^[1].

Animal Model:	Male C57BL/6JOlaHsd mice (4 weeks old)^[1]
Dosage:	200 mg/kg
Administration:	Oral gavage; b.i.d.; 6 weeks
Result:	A slight decrease in body weight and food intake associated with some diarrhea was observed but only during the first few days of treatment.

Clinical Trial

分子量

155.20

Formula

C₆H₁₃N₅

CAS 号

775351-65-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.