TP0556351

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TP0556351

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

TP0556351 是一种有效且具有选择性的基质金属蛋白酶 2 (MMP2)抑制剂，IC₅₀为 0.2 nM。TP0556351 能在 Bleomycin 诱导的肺纤维化小鼠模型肺中降低胶原蛋白数量。TP0556351 可用于研究特发性肺纤维化 (IPF)。

生物活性

TP0556351 is a potent and selectivematrix metalloproteinase-2 (MMP2)inhibitor with anIC₅₀value of 0.2 nM. TP0556351 reduces the amount of collagen in the lungs of a Bleomycin-induced pulmonary fibrosis mouse model. TP0556351 can be used for researching idiopathic pulmonary fibrosis (IPF)^[1].

IC₅₀& Target^[1]

MMP-2

0.2 nM (IC₅₀)

体内研究
(In Vivo)

TP0556351 (0.03, 0.1, 0.3, or 1 mg/kg/day; SC, for 14 days) reduces the amount of collagen in the lungs of a Bleomycin-induced pulmonary fibrosis mouse model^[1].

分子量

1067.15

Formula

C₅₀H₇₀N₁₀O₁₆

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.